depends on the thong, tbh. and maybe your body type too?
Thongs that are too thick you can feel the wedgie, but thongs that are "seamless" and made from a thinner material are super comfy, tbh. Feels like you're wearing nothing. I think sizes tend to run small for thongs compared to other undies, too. Size up and make sure what you're wearing isn't too tight.
You can then wear leggings and other comfy stretchy pants without panty lines, too.